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KMID : 1007519980070010023
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Food Science and Biotechnology
1998 Volume.7 No. 1 p.23 ~ p.27
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Chemical Structures and Isolation of Glucosyltransferase Inhibitor from the Leaves of Korean Persimmon
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An, Bong Jeun
Bae, Man Jong/Choi, Chung
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Abstract
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As a series of studies to find an anti-plaque substance, three compounds have been isolated from the leaves of Korean persimmons. The studies showed a positive reaction in anisaldehyde-H₂SO₄, and FeCL₃solution, which were confirmed through thin layer chromatography with condensed tannin. The components were identified as (+)-gallocatechin, gallocatechin(4α→8)-catechin and prodelphinidin B-3 by spectroscopic analysis. Their inhibitory effects on glucosyltransferase were also investigated and dimeric prodelphinidin B-3, which possessed a 3,4,5-trihydroxylphenyl moiety in ring B of the flavonoid carbon skeleton, showed a higher inhibitory activity than monomeric (+)-gallocatechin. The inhibitory mechanism of (+)-galloeatechin and prodelphinidin B-3 on glucan synthesis by glucosyltransferase was noncompetitive.
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